大颗粒淋巴细胞白血病并发鸟分枝杆菌脑膜炎一例并文献复习

A case of T-cell large granular lymphocyte leukemia complicated with Mycobacterium avium meningitis together with literature review

非结核分枝杆菌中枢神经系统感染在我国较为少见。作者报道了1例鸟分枝杆菌脑膜炎患者。患者为女性,44岁,以“确诊T细胞大颗粒淋巴细胞白血病3年余,发热1d”住院,入院后行脑脊液检测,通过二代基因测序发现感染菌株为鸟分枝杆菌,从而采取了有效的治疗方法,最终鸟分枝杆菌脑膜炎获得治愈。作者通过复习相关文献,讨论了非结核分枝杆菌中枢神经系统感染的治疗方法,提醒临床医师警惕非结核分枝杆菌病的发生及其严重性,尽早明确病因并采取必要的干预措施。

Non-tuberculous mycobacteria(NTM)central nervous system infection is rare in China.The author reported a case of Mycobacterium avium meningitis.The patient was a 44 years old female,admitted to hospital with“diagnosed as T-cell large granular lymphocyte leukemia for more than 3 years,having fever for 1 day”.After admission,cerebrospinal fluid was tested,and Mycobacterium avium was found with cerebrospinal fluid next generation sequencing,then patient was cured with effective treatment for Mycobacterium avium meningitis.By reviewing relevant literature,the author discusses about the treatment of NTM central nervous system infection,reminds clinicians to be alert to the occurrence and severity of NTM disease,to identify the causes as soon as possible and to take necessary intervention measures.