金银花环烯醚萜苷类化学成分和药理活性研究进展

Research progress on chemical constituents and pharmacological activities of iridoid glycosides in Lonicera japonica

金银花作为传统中药材,药用历史悠久,其化学成分复杂,主要包括环烯醚萜苷类、黄酮类、三萜类、有机酸类和挥发油类化合物。其中,环烯醚萜苷类化合物占有较高的比例。此外,现代药理学研究发现,已分离鉴定的环烯醚萜苷多具有抗病毒、抗炎、抗肿瘤、护肝和降血糖等多种药理活性。该文通过检索中、英文数据库,拟对目前金银花中已分离鉴定的环烯醚萜苷类化合物及其药理活性进行系统的归纳整理,以期为金银花的深度开发利用和药材质量标准提升提供参考。

As a traditional Chinese medicinal material, Lonicera japonica has a long medicinal history. The chemical constituents of Lonicera japonica are complex, mainly including iridoid glycosides, flavonoids, triterpenes, organic acids and volatile oil. Iridoid glycosides account for a higher proportion. In addition, modern pharmacological studies have shown that the iridoid glycosides have many pharmacological activities such as antivirus, anti-inflammation, anti-tumor, liver protection and lowering blood sugar. This review intends to systematically summarize the iridoid glycosides identified from Lonicera japonica and their pharmacological activities by searc-hing Chinese and English databases, in order to provide a reference for the further development and utilization of Lonicera japonica and for the improvement of quality standards of medicinal materials.