老年高血压患者致动脉粥样硬化指数与冠心病相关性研究

Association between atherogenic index of plasma and CHD in elderly hypertension patients

目的评估老年高血压患者致动脉粥样硬化指数(AIP)与冠心病的相关性。方法收集2018年8~12月我国10个省市26家社区医院就诊的老年高血压患者2296例,将患者分为冠心病组459例和非冠心病组1837例。比较2组患者的心血管危险因素和血脂指标。采用logistic回归分析AIP与冠心病的相关性。结果冠心病组AIP水平较非冠心病组明显升高[0.08(-0.06,0.27)vs 0.04(-0.14,0.24),P<0.01],多因素logistic回归分析在校正年龄、糖尿病、吸烟、收缩压、舒张压后,TC、TG和AIP仍是冠心病的强危险因素(OR=1.084,95%CI:1.007~1.168,P=0.008;OR=1.111,95%CI:1.027~1.201,P=0.009;OR=1.705,95%CI:1.179~2.465,P=0.005)。结论 AIP可能是老年高血压患者冠心病风险的独立预测因子,且优于常规的血脂指标。

Objective To evaluate the association between atherogenic index of plasma(AIP) and CHD in elderly hypertension patients.Methods A total of 2296 elderly hypertension patients who visited 26 community hospitals in 10 provinces and cities from August 2018 to December 2018 were divided into CHD group(n=459) and CHD-free group(n=1837).The risk factors and lipid indices of CHD were compared between the two groups.The association between AIP and CHD in elderly hypertension patients was analyzed by multivariate logistic regression analysis.Results The AIP was significantly higher in CHD group than in CHD-free group [0.08(-0.06,0.27) vs 0.04(-0.14,0.24),P<0.01].Multivariate logistic regression analysis showed that TC,TG and AIP were the independent risk factors for CHD in elderly hypertension patients even after adjustment for age, DM, smoking, SBP and DBP(OR=1.084,95%CI:1.007-1.168,P=0.008;OR=1.111,95%CI:1.027-1.201,P=0.009;OR=1.705,95%CI:1.179-2.465,P=0.005).Conclusion AIP is an independent risk factor for CHD and is better than routine lipid indices in predicting CHD in elderly hypertension patients.