老年早期2型糖尿病肾病患者血糖波动与氧化应激、炎症及单核细胞自噬的相关性研究

Study on the correlation between blood glucose fluctuation and oxidative stress,inflammation and monocyte autophagy in elderly patients with early type 2 diabetic nephropathy

目的分析老年早期2型糖尿病肾病患者血糖波动与氧化应激、炎症及单核细胞自噬的相关性。方法研究对象为2019年6月至2020年7月我院收治的老年早期2型糖尿病肾病患者116例,动态监测患者血糖波动以及炎症、单核细胞自噬、氧化应激,同时判定指标之间相关性。结果观察组患者MAGE、TG、8-isoPGF2α、MCP-1、IL-6、TNF-α指标均高于对照组,差异有统计学意义(P<0.05)。两组患者HbAlc、FINS、TG、LDL-C、HDL-C指标比较,差异无统计学意义(P>0.05)。回归性分析发现,MAGE、8-isoPGF2α、MCP-1为血糖波动的重要危险因素。观察组患者LC3B-Ⅱ以及LC3B-Ⅰ等水平与对照组比较,差异有统计学意义(P<0.05)。结论血糖波动为老年早期2型糖尿病肾病患者尿白蛋白肌酐比的重要影响因素,且和炎症、氧化应激、单核细胞自噬有较高相关性。

Objective To analyze the correlation between blood glucose fluctuation and oxidative stress,inflammation and monocyte autophagy in elderly patients with early type 2 diabetic nephropathy.Methods A total of 116 elderly patients with early type 2 diabetic nephropathy who were admitted to our hospital from June 2019 to July 2020 were selected to dynamically monitor blood glucose fluctuations,inflammation,and mononuclear cell autophagy and oxidative stress.At the same time,the correlation between the indicators was determined.Results The MAGE,TG,8-isoPGF2α,MCP-1,IL-6,and TNF-αindexes of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).The two groups of patients HbAlc,FINS,TG,Comparison of LDL-C and HDL-C indicators showed no statistically significant difference(P>0.05).Regression analysis found that MAGE,8-isoPGF2α,and MCP-1 were important risk factors for blood glucose fluctuations.LC3B-Ⅱand LC3B in the observation group Compared with the control group at the level of LC3B-Ⅰ,the difference was statistically significant(P<0.05).Conclusion Blood glucose fluctuation is an important factor influencing the urinary albumin-creatinine ratio in elderly patients with early type 2 diabetic nephropathy,and has a high correlation with inflammation,oxidative stress,and monocyte autophagy.