摘要
Main text Energy metabolism has been proposed to be affected in amyotrophic lateral sclerosis(ALS),due to its relationship with SOD1^(G93A)-dependent mitochondrial loss-offunction[1,2].Although the metabolic state and the use of its dysfunction as an early diagnostic criterion have been evaluated in ALS patients by positron emission tomography(PET),preclinical research in animal models is rare.In this study,we imaged glucose metabolism using[^(18)F]-fluorodeoxyglucose(FDG)(NanoScan PET/CT,Mediso Medical Imaging Systems,Hungary)in both male and female mice expressing a mutated human SOD1 variant(hSOD1^(G93A))with ALS-like symptoms,and compared these animals to age-and sex-matched littermate controls(SOD1WT).
基金
BG was funded by a Kempestiftelserna grant to DM and FS.This study was also supported by the Department of Integrative Medical Biology,UmeåUniversity(DM and FS)and from Umea University Medical Faculty(DM).Open Access funding provided by Umea University.
