自身免疫性疾病流行病学研究进展

Research advances in the epidemiology of autoimmune diseases

自身免疫性疾病(autoimmune diseases,AIDs)是由免疫系统对自身抗原失去免疫耐受,进一步诱发组织损伤和炎症反应并最终导致靶器官受损的一类慢性疾病。这类疾病确切的病因及发病机制至今未明,目前尚不能彻底治愈,极大地影响了患者的劳动力和生活质量,甚至威胁患者生命,消耗大量卫生资源,已成为影响人类健康的重要的公共卫生问题。在过去几十年,AIDs的流行病学研究取得了有目共睹的成就,极大促进了AIDs的诊断、治疗、预后及病因研究。本文对AIDs的流行病学研究进展进行了概述,旨在为AIDs防控策略的制定及未来的研究方向提供一些新的见解和参考。

Autoimmune diseases(AIDs)are a heterogeneous group of diseases characterized by the loss of self-tolerance,which leads to prolonged inflammation and subsequent tissue damage.The exact etiology and pathogenesis of this type of disease have not been fully elucidated.As incurable diseases,AIDs significantly affects the labor force and the quality of life of patients and even threatens the lives of cases.Autoimmune diseases have become one of the major health problems worldwide,constituting a heavy burden to society and are often debilitating and disabling for affected individuals.In the past decades,epidemiological research of AIDs has made remarkable achievements,which greatly promoted the diagnosis,treatment,prognosis,and etiology of AIDs.This article provides an overview of the development of AIDs epidemiological research,aiming to offer some new insights and references for the formulation of AIDs prevention and control strategies and future research directions.