中链饱和脂肪酸与口腔癌发病风险的关联性

Relationship between medium-chain saturated fatty acids and risk of oral cancer

目的探讨膳食中链饱和脂肪酸与口腔癌发病的关联。方法本病例对照研究以面访式问卷的形式调查2013年11月14日至2019年3月21日在福建医科大学附属第一医院口腔颌面外科确诊的225例新发口腔癌患者及527例健康对照。以对照组中能量校正后的各类脂肪酸每日摄入量的中位数进行分组,进行非条件Logistic回归分析模型分析、分层分析及相乘交互作用分析。结果高水平组的总中链饱和脂肪酸、辛酸、癸酸、十一烷酸及月桂酸等与口腔癌的发病风险呈正相关,其调整后的OR值及其95%CI值分别为3.19(95%CI:2.17~4.69)、2.54(95%CI:1.75~3.69)、2.56(95%CI:1.76~3.71)、5.00(95%CI:3.27~7.64)和3.09(95%CI:2.10~4.54)。在不吸烟者中,辛酸和癸酸与口腔癌发生风险呈正相关,且无论是否饮酒,其均能增加口腔癌的发病风险;各亚组均发现高总中链饱和脂肪酸、十一烷酸及月桂酸摄入量与口腔癌发生风险呈正相关。此外,中链饱和脂肪酸与吸烟、饮酒存在相乘交互作用。结论较高水平的膳食中链饱和脂肪酸可能会增加口腔癌的发病风险。

Objective To investigate the association between dietary medium-chain saturated fatty acids and the risk of oral cancer.Methods A case-control study was conducted in 225 patients with diagnosed oral cancer and 527 controls.All participants were recruited from the First Affiliated Hospital of Fujian Medical University from November 14,2013 to March 21,2019.The median daily intake of all kinds of fatty acids after energy correction in the control group was divided into groups.Unconditional Logistic regression analysis stratified analysis and multiplicative interaction analysis were performed,stratified analysis and multiplicative interaction analysis were performed to investigate the relationship between medium chain saturated fatty acids and the risk of oral cancer.Results Compared with the low-level group,the total medium-chain saturated fatty acids,octanoic acid,decanoic acid,undecanoic acid and lauric acid in the high-level group may increase the risk of oral cancer.The adjusted OR and 95%CI were 3.19(95%CI:2.17-4.69),2.54(95%CI:1.75-3.69)、2.56(95%CI:1.76-3.71)、5.00(95%CI:3.27-7.64)and 3.09(95%CI:2.10-4.54),respectively.Stratified analysis showed that octanoic acid and decanoic acid were risk factors of oral cancer among non-smokers,and they may also increased the risk of oral cancer regardless of drinking status.There was a positive correlation between the daily intake of total medium-chain saturated fatty acids,undecanoic acid and lauric acid and the risk for oral cancer regardless of smoking and drinking status.In addition,there were multiplicative interactions between medium-chain saturated fatty acids and smoking or drinking status.Conclusion A higher level of dietary medium-chain saturated fatty acids may increase the risk of oral cancer.