脑白质疏松相关危险因素分析

Analysis of leukoaraiosis related risk factors

目的:分析脑白质疏松(LA)相关的危险因素。方法:选取2019年7月至2020年12月温州市人民医院神经内科188例住院患者,根据是否存在LA分为病例组(78例)和对照组(110例)。分别收集两组年龄、性别、高血压病、糖尿病、血生化、尿微量白蛋白等指标。对两组资料进行单因素比较,对有意义因素进行多因素logistic回归分析。结果:单因素分析中病例组年龄、同型半胱氨酸、高血压病、尿微量白蛋白阳性显著高于对照组,差异有统计学意义(P<0.05);经过多因素logistic回归分析显示年龄(OR=1.163,95%CI=1.107~1.221,P<0.001)、尿微量白蛋白阳性(OR=2.599,95%CI=1.132~5.966,P=0.024)、高血压病(OR=2.767,95%CI=1.223~6.261,P=0.015)仍是LA的独立危险因素。结论:年龄、尿微量白蛋白阳性、高血压病与LA独立相关。

Objective:To analyze the risk factors of leukoaraiosis.Methods:A total of 188 inpatients were selected from the Department of Neurology,Wenzhou People’s Hospital from July 2019 to December 2020.According to the presence or absence of leukoaraiosis(LA),the patients were divided as case group(78 cases)and control group(110 cases).Age,gender,hypertension,diabetes,blood biochemical,and microalbuminuria indexes of both groups were collected.The univariate comparison was conducted in the data of the two groups,and multivariate logistic regression analysis was made of the significant factors in the univariate comparison.Results:Univariate analysis showed statistical difference(P<0.05)between the two groups,with the case group significantly higher positive rate of age,homocysteine,hypertension and microalbuminuria than the control group.Multivariate logistic regression analysis showed that age(OR=1.163,95%CI=1.107-1.221),microalbuminuria(OR=2.599,95%CI=1.132-5.966),and hypertension(OR=2.767,95%CI=1.223-6.261)remain to be independent risk factors for leukoaraiosis.Conclusion:Age,microalbuminuria and hypertension were independently related to leukoaraiosis.