探讨煤工尘肺合并非小细胞肺癌患者中P53基因蛋白的表达

To investigate the expression of P53 gene protein in patients with coal workers'pneumoconiosis complicated with non-small cell lung cancer

目的探究煤工尘肺合并肺癌患者中P53基因蛋白的表达。方法选取2017年1月至2019年1月本院收治的煤工尘肺合并非小细胞肺癌患者64例作为研究组,另选取同时期本院收治的按确诊时间顺序符合入组条件的前64例非职业病相关的男性非小细胞肺癌患者作为对照组。比较两组患者的P53基因蛋白表达结果,P53基因蛋白表达结果与淋巴结转移及生存期的关系。结果研究组P53基因蛋白表达阳性率明显高于对照组(P<0.05);研究组鳞状细胞癌的P53基因蛋白表达阳性率明显高于对照组(P<0.05),而研究组腺癌P53基因蛋白表达阳性率明显低于对照组(P<0.05);研究组淋巴结转移阳性率明显高于对照组(P<0.05),研究组无淋巴结转移阳性率明显低于对照组(P<0.05);两组淋巴结转移阳性率明显高于无淋巴结转移阳性率(P<0.05);研究组生存时间≤18个月的阳性率明显高于对照组(P<0.05),研究组的生存时间>18个月的阳性率明显高于对照组(P<0.05);两组患者生存时间≤18个月的阳性率明显高于生存时间>18个月的阳性率(P<0.05)。结论煤工尘肺合并非小细胞肺癌患者机体内的P53基因蛋白表达的检测结果能清晰反映机体内淋巴结转移的关系以及术后生存期,为煤工尘肺合并非小细胞肺癌的临床综合诊断和临床治疗提供重要的参考依据。

Objective To explore the expression of P53 gene protein in patients with coal workers'pneumoconiosis complicated with lung cancer.Methods 64 patients with coal workers'pneumoconiosis combined with non-small cell lung cancer admitted to our hospital from January 2017 to January 2019 were selected as the study group,and the first 64 patients with non-occupational disease-related male non-small cell lung cancer admitted to our hospital during the same period who met the inclusion criteria according to the chronological order of diagnosis were selected as the control group.The results of P53 gene protein expression,the relationship between P53 gene protein expression and lymph node metastasis and survival were compared between the two groups.Results The positive expression rate of P53 gene protein in the study group was significantly higher than that in the control group(P<0.05).The positive rate of P53 gene protein expression in squamous cell carcinoma of the study group was significantly higher than that of the control group(P<0.05),while the positive rate of P53 gene protein expression in adenocarcinoma of the study group was significantly higher than that of the control group(P<0.05).The positive rate of lymph node metastasis in the study group was significantly higher than that in the control group(P<0.05),and the positive rate of no lymph node metastasis in the study group was significantly lower than that in the control group(P<0.05).The positive rate of lymph node metastasis in two groups was significantly higher than that without lymph node metastasis(P<0.05).The positive rate of survival time≤18 months in the study group was significantly higher than that in the control group(P<0.05),and the positive rate of survival time>18 months in the study group was significantly higher than that in the control group(P<0.05).The positive rate of survival time≤18 months in two groups was significantly higher than that of>18 months(P<0.05).Conclusion Of coal workers pneumoconiosis combined non-small cell lung cancer patient P53 gene protein expression in body for testing,the test result can reflect clearly the relationship between lymph node metastasis and the postoperative survival in body,coal workers pneumoconiosis combined with non-small cell lung cancer clinical comprehensive diagnosis and clinical treatment provides important reference basis.