受体相互作用蛋白1和受体相互作用蛋白3在细胞信号转导通路中的作用

Role of RIP1 and RIP3 in Cell Signal Transduction Pathways

受体相互作用蛋白(RIP)家族成员均含有1个丝氨酸-苏氨酸激酶结构域。RIP1被上游信号激活泛素化后可引起下游炎症通路的激活,而RIP1去泛素化并与RIP3结合后可激活下游的凋亡及坏死性凋亡信号通路。因此,研究RIP1和RIP3作为关键分子直接参与的炎症、凋亡及坏死性凋亡信号通路,可为治疗炎症性疾病、退行性疾病、肿瘤及衰老等提供新思路。未来作用于RIP相关信号通路的新的化学抑制剂的发现,有助于精细调控细胞信号转导过程,为临床诊疗提供新途径。

Members of receptor-interacting protein(RIP)family all contain a serine-threonine kinase domain.When activated and ubiquidized by upstream signals,RIP1 can cause activation of downstream inflammatory pathways,while deubiquitinated,RIP1 can combine with RIP3,jointly activate downstream signaling pathways of apoptosis and necroptosis.Therefore,studying the signaling pathways of inflammation,apoptosis and necroptosis that RIP1 and RIP3 are involved as key molecules,can provide new ideas for the treatment of inflammatory diseases,degenerative diseases,tumors,aging and so on.In the future,the discovery of new chemical inhibitors functioning on RIP related signaling pathways will also help regulate the cell signal transduction process and provide new ways for the clinical diagnosis and treatment.