子宫内膜异位症动物模型建立方法

Establishment Methods of Animal Models of Endometriosis

子宫内膜异位症(EMT)是现代女性的多发性疾病,在现代临床中本病复发率高,其病因及发病机制仍不明确,目前尚无有效的根治方法。实验研究是EMT研究的必要手段,但受到医学伦理及道德的约束,不能进行人体的多次创伤及试验性研究,故通过构建EMT动物模型进行相关研究,其造模方法主要包括自发性、诱发性以及种植性,诱发性动物模型包括手术移植、药物诱导、经血逆流等,手术移植法操作简单、可控,已在近年研究中应用,并可能成为未来复建EMT动物模型的主要方法。

Endometriosis(EMT)is a common disease among modern women,with a high recurrence rate in modern clinical practice.Its etiology and pathogenesis are still unclear,and there is no effective radical cure at present.Experimental research is a necessary means for the study of EMT,however limited by the medical ethics and moral constraint,multiple trauma and experimental study of the human body cannot be performed,therefore,the studies are carried out by establishing the EMT animal model.The establishment methods mainly include spontaneous,inducing and implanting methods,and the induced animal models include transplantation surgery,drug induction,retrograde menstruation etc.The surgical transplantation method is simple and controllable,which has been applied in recent studies,and may become the main method for the reconstruction of EMT animal models in the future.