睡眠紊乱、消退记忆与创伤后应激障碍的相关性研究进展

Research Progress on the Correlation Between Sleep Disorders,Fading Memory and Post-traumatic Stress Disorder

创伤后应激障碍(Post-traumatic Stress Disorder,PTSD)伴随有睡眠紊乱,条件性恐惧消退的学习和记忆能力受损。创伤事件之后,睡眠障碍,如失眠、噩梦,和碎片化快速眼动睡眠预测了PTSD症状的后续发展。急性创伤引起的睡眠障碍,可能导致消退记忆不能持续和泛化,从而发展和延续了PTSD症状。现就睡眠紊乱、消退记忆及PTSD之间的关系进行综述,认为睡眠障碍导致消退记忆的巩固和泛化受损仍然是将来研究PTSD神经机制的重要方向。

Post-traumatic stress disorder(PTSD)is associated with sleep disorders and impairment of learning and memory in the extinction of conditioned fear.After a traumatic event,sleep disorders,such as insomnia,nightmares,and fragmented REM sleep,predict the subsequent development of PTSD symptoms.The sleep disorders caused by the acute trauma may result in failure of continuation and generalization of memories,which may develop and perpetuate the symptoms of PTSD.This paper reviewed the relationship between sleep disorders,memory impairment,and PTSD.It is believed that the topic of consolidation and damaged generalization of fading memory due to sleep disorders is still important in studying the neural mechanism of PTSD in the future.