缺氧性肺动脉高压治疗新靶点研究-PGC-1α

Research in new target treatment of hypoxic pulmonary hypertension-PGC-1α

肺动脉高压特征是肺血管阻力升高和进行性右心室肥大,导致右心衰竭甚至最终死亡,其病因涉及环境、遗传等因素,发病机制尚不明确,缺乏有效的治疗手段。新近发现过氧化物酶体增殖物受体辅助激活因子-1α在缺氧性肺动脉高压的肺血管重构及右心室肥厚中均有重要作用,有望成为治疗缺氧性肺动脉高压新的分子靶点。

Pulmonary hypertension is characterized by elevated pulmonary vascular resistance and progres-sive right ventricular hypertrophy leading to right heart failure and even death.The etiology of pulmonary hy-pertension involves environmental,genetic and other factors,its pathogenesis is still unclear and there is yet no effective means for treatment.It has recently been found that peroxisome proliferator activated receptor co-activator1αplayed an important role in pulmonary vascular remodeling and right ventricular hypertrophy in hypoxic pulmonary hypertension,which could become a new molecular target for the treatment of hypoxic pulmonary hypertension.