帕利哌酮联合重复经颅刺激治疗老年精神分裂症的临床效果

Clinical effect of paliperidone combined with repetitive transcranial stimulation in the treatment of senile schizophrenia

目的:探讨帕利哌酮联合重复经颅刺激治疗老年精神分裂症的临床效果。方法:2018年3月-2019年7月收治老年精神分裂症患者80例,随机分为两组。对照组应用帕利哌酮治疗,研究组在帕利哌酮基础上联用重复经颅刺激治疗。比较两组治疗效果。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组治疗8周后简易精神状态检查量表(MMSE)评分高于对照组,阳性与阴性症状量表(PANSS)及ADL量表评分均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:帕利哌酮联合重复经颅刺激治疗老年精神分裂症的效果及安全性良好。

Objective:To explore the clinical effect of paliperidone combined with repetitive transcranial stimulation in the treatment of senile schizophrenia.Methods:From March 2018 to July 2019,80 elderly patients with schizophrenia were selected and randomly divided into two groups.The control group was treated with paliperidone.The study group treated with paliperidone combined with repetitive transcranial stimulation.The therapeutic effect between the two groups was compared.Results:The total effective rate of the study group was higher than the control group,with the difference was statistically significant(P<0.05).After 8 weeks of treatment,the MMSE scale scores in the study group were higher than the control group,and the PANSS and ADL scale scores were lower than the control group,with the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Paliperidone combined with repetitive transcranial stimulation is effective and safe in the treatment of elderly schizophrenia.