纳洛酮联合呼吸机对慢性阻塞性肺疾病合并呼吸衰竭患者肺功能的影响

The effect of Naloxone combined with ventilator on pulmonary function in patients with chronic obstructive pulmonary disease complicated with respiratory failure

目的:分析纳洛酮联合呼吸机治疗对慢性阻塞性肺疾病(简称慢阻肺)合并呼吸衰竭患者肺功能的影响。方法:2015年12月-2016年10月收治慢阻肺合并呼吸衰竭患者68例,随机分为两组,各34例。两组患者入院后进行常规治疗,并同时采用呼吸机治疗,呼吸机选用S/T模式,试验组增加静脉注射纳洛酮治疗,比较两组患者治疗前后肺功能与血气指标水平。结果:试验组治疗后血氧分压(PaO2)水平明显高于对照组,二氧化碳分压(PaCO2)水平明显低于对照组,差异有统计学意义(P<0.05);试验组治疗后最大呼气峰流速值(PEF)、肺活量25%和50%时的呼气流速(PEF25、PEF50)、肺总量(TCL)等指标水平均高于对照组,差异有统计学意义(P<0.05)。结论:在临床治疗中纳洛酮联合呼吸机治疗慢阻肺合并呼吸衰竭患者的疗效优于单纯使用呼吸机治疗的效果,能够有效改善患者血气指标水平与肺功能指标水平。

Objective:To analyze the effect of Naloxone combined with ventilator therapy on lung function in patients with COPD complicated with respiratory failure.Methods:From December 2015 to October 2016,68 cases of patients with COPD and respiratory failure were enrolled,they were randomly divided into two groups with 34 cases in each group.After admission,all patients received conventional treatment and they were treated with a ventilator at the same time,the ventilator used the S/T mode,and the experimental group increased intravenous injection of Naloxone treatment.The lung function and blood gas index levels were compared between the two groups before and after treatment.Results:The level of PaO2 in the experimental group was significantly higher than that in the control group,and the level of PaCO2 was significantly lower than that in the control group,the differences were statistically significant(P<0.05).The indexes levels of PEF,PEF25,PEF50 and TCL in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Naloxone combined with ventilator in the treatment of COPD complicated with respiratory failure is better than that of ventilator alone,which can effectively improve the level of blood gas indexes and pulmonary function indexes.