苯巴比妥联合安定用于急诊小儿惊厥的临床效果及有效率评价

Evaluation on the clinical effect and effective rate of phenobarbital combined with diazepam in the treatment of emergency pediatric convulsions

目的:探究苯巴比妥联合安定用于急诊小儿惊厥的临床效果。方法:2018年5月-2019年10月收治小儿惊厥患儿100例,随机分为两组,各50例。观察组给予苯巴比妥联合安定治疗;对照组给予安定治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组IgA、IgM、IgG、CD8+水平均低于对照组、CD4+、CD4+/CD8+水平均高于对照组,差异有统计学意义(P<0.05);观察组治疗后神经元特异性性烯醇化酶(NSE)、S-100β蛋白(S-100β)、脑源性神经营养因子(BDNF)水平均低于对照组,差异有统计学意义(P<0.05)。结论:苯巴比妥联合安定用于急诊小儿惊厥中的效果显著,且能够降低血清指标水平,改善免疫功能。

Objective:To investigate the clinical efficacy and effective rate of phenobarbital combined with diazepam in the treatment of emergency pediatric convulsions.Methods:From May 2018 to October 2019,100 cases of children with convulsions were enrolled,they were randomly divided into two groups with 50 cases in each group.The observation group was given phenobarbital combined with diazepam.The control group was given diazepam.The therapeutic effects between the two groups was compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The IgA,IgM,IgG and CD8+levels of the observation group were lower than those of the control group,and the CD4+,CD4+/CD8+levels were higher than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of NSE,S-100βand BDNF in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Phenobarbital combined with diazepam has a significant effect on emergency pediatric convulsions,which can reduce the levels of serological indicators and improve immune function of children.