2000~2020年国内前列腺炎研究回顾与展望——基于知识图谱的当代学科发展动向研究

Prostatitis studies in China from 2000 to 2020: A Knowledge Atlas-based study on the development trend of contemporary disciplines

目的:回顾并分析近二十年国内的前列腺炎研究动向。方法:检索CNKI(中国知识基础设施工程)核心期刊集中前列腺炎文献,用Excel,Citespace及VOSviewer对数据进行分析。结果:纳入文献1216篇原始研究文献,关键词3271个。其中频次3次及以上的占比12.9%,前5位是慢性前列腺炎、前列腺炎、chronic prostatitis、prostatitis以及前列腺液等词,中心性均超过300。前列腺炎重点研究领域被划分为八大主题,集中在前列腺炎、前列腺液、大鼠、前列腺、综合病症、疗效观察、复方(中药)/治疗应用等。纳入文献涉及作者2808例次、符合超过2次的作者有402例次,大多数作者群较为分散。近二十年的研究主题,由2000~2001年研究主题集中在中药疗法、活血化瘀以及护理综合等方面转向2007~2010年期间多基于动物模型、CD4+淋巴细胞等实验分子学热点研究领域,再向2013~2016年间的尿动力学、危险因素以及特异抗原的一大热点,转至集中近在2016年的文献信息资源这一研究热点。结论:未来研究可预,免疫机制仍然不明确,免疫机制在前列腺炎中仍是未来研究一大热点方向。治疗方面,中医药具有潜在价值,而如何把中西医二者真正的结合起来,还需要进一步的实践和研究。前列腺炎研究需要加强协同建立关键词权威来源渠道,纳入国家标准体系,促进优化共建共享,融入多学科研究、多角度与现有成果双双结合,努力消除学术壁垒,多方协同创新,促进学科交流发展。

Objective:To review and analyze the trend of researches on prostatitis in China in the past two decades.Methods:We searched the core collection of China National Knowledge Infrastructure(CNKI)for studies on prostatitis,and analyzed the data obtained using Excel,Citespace and VOSviewer.Results:Totally,1216 original articles were identified,with 3271 keywords,≥3-time high-frequency keywords accounting for 12.9%,with"慢性前列腺炎","前列腺炎","chronic prostatitis","prostatitis",and"前列腺液"as the top 5 ones,each with a centrality higher than 300.Major prostatitis-related studies focused on the 8 keywords,namely,prostatitis,prostatic fluid,rats,prostate,syndromes,efficacy observation,compound(in traditional Chinese medicine,TCM),and therapeutic application.The included literature involved 2808 authors,with 402 involved more than twice and most of them in a scattered manner.The major topics of prostatitis studies varied in the past two decades,focusing on TCM therapies,promotion of blood circulation and stasis and comprehensive nursing in 2000-2001,on animal models,CD4+lymphocytes and other experimental molecules in 2007-2010,on urodynamics,risk factors and specific antigens in 2013-2016,and on literature information resources in 2016.Conclusion:The immune mechanism remains a hot topic in the future researches on prostatitis.In terms of treatment of the disease,TCM has a potential value,and more practice and studies are required for an optimal combination of TCM and Western medicine.Strengthened collaborative efforts are needed to establish an authoritative source channel for the keywords,and incorporate it into the national standard system,and above all,to integrate the prostatitis study into multi-disciplinary researches,eliminate academic barriers,encourage collaborative innovation with multiple parties,and promote the exchanges and development in this field.