格列美脲与二甲双胍联用治疗老年精神病合并糖尿病患者的治疗有效率分析

Analysis of the Effective Rate of Glimepiride and Metformin in the Treatment of Elderly Patients with Psychosis and Diabetes

目的评析老年精神病合并糖尿病患者在二甲双胍治疗之上联合格列美脲的价值。方法选择该院2017年8月—2019年8月期间接诊的78例老年精神病合并糖尿病患者,在随机数字表法下分为参照组与观察组,接受二甲双胍治疗的小组为参照组,接受格列美脲、二甲双胍治疗的小组为观察组,统计对比两组HOMA-IR、HOMA-β、HbAlc、FPG、2 hPG、不良反应发生率、BPRS评分、SDSS评分。结果观察组HOMA-IR(1.35±0.36)、HOMA-β(48.32±6.28)均优于参照组HOMA-IR(2.31±0.42)、HOMA-β(40.28±5.73),差异有统计学意义(P<0.05)。观察组的HbAlc(6.05±1.59)%、FPG(6.25±1.37)mmol/L、2 hPG(8.12±1.32)mmol/L均低于参照组HbAlc(8.12±1.89)%、FPG(8.11±1.34)mmol/L、2 hPG(10.39±1.55)mmol/L,差异有统计学意义(P<0.05)。观察组不良反应发生率(5.13%)小于参照组(28.21%),差异有统计学意义(P<0.05)。观察组BPRS评分(1.24±0.52)分、SDSS评分(1.02±0.21)分小于参照组BPRS评分(2.89±0.86)分、SDSS评分(1.82±0.22)分,差异有统计学意义(P<0.05)。结论老年精神病合并糖尿病患者采用格列美脲与二甲双胍联用治疗可以取得显著成效,值得在临床中开展使用和推广。

Objective To evaluate the value of combined treatment with glimepiride on metformin in elderly patients with psychosis and diabetes.Methods 78 elderly patients with mental illness and diabetes who were admitted in the hospital from August 2017 to August 2019 were selected and divided into the reference group and the observation group under the random number table method.The group receiving metformin treatment was named the reference group.The group receiving glimepiride and metformin was the observation group.The two groups were statistically compared with HOMA-IR,HOMA-β,HbAlc,FPG,2 hPG,incidence of adverse reactions,BPRS score,and SDSS score.Results The observation group HOMA-IR(1.35±0.36)and HOMA-β(48.32±6.28)were better than the reference group HOMA-IR(2.31±0.42),HOMA-β(40.28±5.73),the difference was statistically significant(P<0.05).HbAlc(6.05±1.59)%,FPG(6.25±1.37)mmol/L and 2 hPG(8.12±1.32)mmol/L of the observation group were lower than those of the reference group HbAlc(8.12±1.89)%,FPG(8.11±1.34)mmol/L,2 hPG(10.39±1.55)mmol/L,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(5.13%)was lower than that in the reference group(28.21%),the difference was statistically significant(P<0.05).The observation group's BPRS score(1.24±0.52)points and SDSS score(1.02±0.21)points were lower than the reference group's BPRS score(2.89±0.86)points and SDSS score(1.82±0.22)points,the difference was statistically significant(P<0.05).Conclusion The combined treatment of glimepiride and metformin in elderly patients with psychosis and diabetes can achieve significant results,and it is worthy of clinical use and promotion.