采用小剂量胰岛素持续滴注治疗小儿糖尿病酮症酸中毒的有效性研究

Study on the Effectiveness of Continuous Infusion of Low-dose Insulin in the Treatment of Children with Diabetic Ketoacidosis

目的探究小儿糖尿病酮症酸中毒治疗中采用小剂量胰岛素持续滴注治疗方案的临床治疗效果及炎症因子指标变化情况。方法该项研究开展于2018年12月—2020年12月期间,研究对象主要为糖尿病酮症酸中毒患儿100例;均分为两组,对照组采用常规胰岛素治疗方案;观察组采用小剂量胰岛素持续滴注治疗方案;分析患儿临床治疗相关指标以考察小剂量胰岛素持续滴注的治疗价值。结果观察组患儿临床相关指标改善明显,患儿临床相关指标均优于对照组,且住院时间低于对照组,组间比较差异有统计学意义(P<0.05);观察组患儿治疗后炎症因子水平明显优于对照组,差异有统计学意义(P<0.05);两组患儿治疗后生活质量各项评分均较干预前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组患儿临床治疗疗效良好,患儿不良反应发生率较低,组间比较差异有统计学意义(P<0.05)。结论糖尿病酮症酸中毒患儿经小剂量胰岛素治疗后,可实现患儿血糖水平的控制,患儿发生不良反应的情况较小,生活质量评分有所提升,因此临床治疗中应重视患儿胰岛素剂量的有效控制。

Objective To explore the clinical therapeutic effect and changes of inflammatory factors in the treatment of pediatric diabetic ketoacidosis with continuous infusion of low-dose insulin.Methods This study was carried out from December 2018 to December 2020.The main subjects of the study were 100 children with diabetic ketoacidosis.The two groups were divided equally into two groups.The control group was treated with conventional insulin therapy;the observation group was treated with the treatment plan of continuous infusion of small dose of insulin;analyzed the relevant indicators of clinical treatment in children to investigate the therapeutic value of continuous infusion of low dose of insulin.Results The clinical indicators of the observation group were significantly improved.The clincal-related indicators of the children were better than those of the control group,and the length of hospital stay was lower than that of the control group.The difference between the groups was statistically significant(P<0.05);the level of inflammatory factors in the observation group was significantly better after treatment than the control group,the difference was statistically significant(P<0.05);the scores of the quality of life of the two groups of children after treatment were higher than those before the intervention,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Observation group children had good clinical treatment effect,the incidence of adverse reactions in children was relatively low,and the difference between groups was statistically significant(P<0.05).Conclusion Children with diabetic ketoacidosis can achieve control of their blood glucose levels after treatment with low-dose insulin.Children have less adverse reactions,and their quality of life scores have been improved.Therefore,the effective control of insulin dose in children should be emphasized in clinical treatment.