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吴茱萸汤联合西药治疗反流性食管炎的临床观察 被引量:7

Clinical observation of Wuzhuyu Decoction combined with synthetic medicines in treating reflux esophagitis
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摘要 目的观察吴茱萸汤联合西药治疗反流性食管炎(RE)的临床疗效。方法选取脾胃虚寒型RE患者1026例,随机分成观察组和对照组,各513例,对照组患者给予奥美拉唑肠溶片口服治疗,观察组在对照组治疗的基础上联合吴茱萸汤治疗。比较2组的临床疗效、胃镜疗效、中医症候积分、生活质量、血清胃泌素(GAS)、胃动素(MTL)水平及不良反应。结果观察组临床总有效率(91.72%)高于对照组(79.57%),P<0.05;观察组胃镜总有效率(92.70%)高于对照组(83.10%),P<0.05;观察组治疗后中医症候积分和生活质量评分均低于对照组(P<0.05);治疗后观察组血清GAS和MTL水平均明显高于对照组(P<0.05);对照组不良反应发生率(9.04%)高于观察组(6.51%),P>0.05。结论脾胃虚寒型RE患者采用吴茱萸汤联合西药治疗疗效明确,可明显改善临床症状,提高GAS和MTL水平,提升生活质量且较为安全。 Objective To investigate the clinical effect of Wuzhuyu Decoction combined with synthetic medicines in treating reflux esophagitis(RE).Methods 1026 RE patients of deficiency-cold of spleen and stomach syndrome were divided into 2 groups by random method,each with 513 cases.The control group received Omeprazole Enteric-coated Tablets orally.Based on this,the observation group received Wuzhuyu Decoction.The clinical efficacy,gastroscopy efficacy,TCM symptom score,quality of life,serum gastrin(GAS)and motilin(MTL)levels and adverse reactions were compared between the 2 groups.Results The total clinical effective rate was significantly higher in observation group than in control group(91.72%vs 79.57%,P<0.05).The total effective rate of gastroscope was significantly higher in observation group than in control group(92.70%vs 83.10%,P<0.05).After treatment,the observation group had lower TCM syndrome score and quality of life score than those in control group(P<0.05).The serum levels of GAS and MTL were higher in observation group than in control group(P<0.05).The incidence of adverse reactions was slightly higher in control group than that in observation group(9.04%vs 6.51%,P>0.05).Conclusion Application of Wuzhuyu Decoction combined with synthetic medicine in treating RE can effectively and safely improve the clinical symptoms,gastrin and motilin levels,thus improve the quality of life.
作者 冯昊 李明 任晓静 张逊 袁金斌 郭晓双 FENG Hao;LI Ming;REN Xiaojing;ZHANG Xun;YUAN Jinbin;GUO Xiaoshuang(Department of Pharmacy,Tangshan Union Medical College Hospital,Tangshan 063000,China;Department of Pharmacy,Tangshan People′s Hospital,Tangshan 063000,China;Department of Pharmacy,Kailuan General Hospital,Tangshan,Tangshan 063000,China;Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处 《西北药学杂志》 2021年第4期656-659,共4页 Northwest Pharmaceutical Journal
基金 河北省中药管理局2018年度中医药类科研计划课题(编号:2018336)。
关键词 吴茱萸汤 脾胃虚寒 反流性食管炎(RE) 临床疗效 Wuzhuyu Decoction deficiency-cold of spleen and stomach reflux esophagitis(RE) clinical effect
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