加味当归芍药散联合氨甲环酸治疗黄褐斑临床观察

Clinical Observation of Modified Danggui Shaoyao Powder Combined with Tranexamic Acid in the Treatment of Chloasma

目的探讨加味当归芍药散联合氨甲环酸治疗黄褐斑的临床疗效。方法选取2016年6月—2018年8月于南京中医药大学附属医院皮肤科就诊的87例中老年女性黄褐斑患者进行研究,随机分为对照组(44例)及治疗组(43例)。对照组采用口服氨甲环酸治疗,治疗组在对照组的基础上联合加味当归芍药散治疗,2组患者均连续治疗3个月。对比观察2组患者面部色斑面积及颜色,计算色斑总积分及下降指数,并记录治疗期间的不良反应。结果治疗后,治疗组患者治疗总有效率90.0%(36/40)显著高于对照组72.5%(29/40)(P<0.05);2组患者治疗后色斑面积及颜色均有不同程度的改善,色斑总积分均明显低于治疗前(P<0.05);治疗组与对照组相比较,治疗组色斑总积分下降指数显著升高(P<0.05);治疗组不良反应总发生率为7.5%(3/40);对照组不良反应总发生率为10.0%(4/40),差异无统计学意义(P>0.05)。结论加味当归芍药散联合氨甲环酸治疗黄褐斑疗效显著,值得临床推广应用。

Objective To investigate the effect of modified Danggui Shaoyao powder combined with tranexamic acid in the treatment of chloasma.Methods 87 cases of middle-aged and elderly female chloasma patients were selected.They were randomly divided into control group and treatment group.Patients in both groups were given tranexamic acid orally,while the treatment was added modified Danggui Shaoyao powder.The course of treatment was 3 months.The area and color of chloasma were observed,the total integral and decline index were calculated,and the complications and adverse reactions during the treatment were recorded.Results After treatment,the total effective rate in the treatment group was 90.0%(36/40)significantly higher than that in the control group(72.5%(29/40)(P<0.05).After treatment,the area and color of the plaques in 2 groups were improved to varying degrees,and the total score of the plaques was significantly lower than that before treatment(P<0.05).Compared with the control group,the decreasing index of the total score of color spots in the treatment group was significantly increased(P<0.05).The incidence of adverse reactions in the treatment group was 7.5%(3/40).The incidence of total adverse reactions in the control group was 10.0%(4/40),with no statistical significance(P>0.05).Conclusion The clinical effect of modified Danggui Shaoyao powder combined with tranexamic acid in the treatment of chloasma is significant,which is significantly better than that of tranexamic acid alone,which is worthy of clinical application.