天然色素栀子黄的危害评估研究

Hazard assessment of health effects of Gardenia Yellow

目的基于栀子黄色素及其主成分已有的毒理学资料,对栀子黄色素开展危害评估、关键效应和剂量的基准剂量分析。方法采用系统文献检索方法,制定检索策略,收集栀子黄色素毒理学资料,并根据亚慢性毒性实验结果,应用基准剂量法测算关键效应和剂量。结果藏红花酸及其酯类是栀子黄色素中的主要成分,主要毒性作用靶器官是肝脏和肾脏,尚未发现特殊毒性。栀子苷是栀子黄色素的主要毒性成分,具有明显的肝肾毒性。栀子黄色素的无可见不良作用水平(NOAEL)为0.5 g/kg BW,应用基准剂量法计算出以肾脏毒性为关键终点的BMDL10为0.46 g/kg BW。结论肾小管上皮细胞色素沉着是栀子黄色素的敏感毒效应,栀子黄风险评估需进一步补充人群暴露资料,本研究可为进一步开展栀子黄色素的人群摄入风险评估提供参考。

Objective Hazard assessment of gardenia yellow were performed based on the existing toxicological data.Methods The systematic literature searches(SLS)was used to collect toxicological data.Then,the reference dose method was employed to calculate the key toxic effects according to the results of subchronic toxicity test.Results Crocin is the main components of gardenia yellow,and no special toxicity has been found,but its toxic target organs may be liver and kidney.Geniposide is the main toxic component and has obvious hepatorenal toxicity.The NOAEL of gardenia yellow is 0.5 g/kg BW.The BMDL10 with nephrotoxicity as the key end point is calculated as 0.46 g/kg BW by reference dose method.Conclusion Renal tubular epithelial cytopigmentation is the sensitive toxic effect of gardenia yellow.This study can provide a basis for further population intake risk assessment.