髓源抑制性细胞免疫抑制功能及其在寄生虫感染领域的研究进展

Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection

髓源抑制性细胞(MDSC)是一群未成熟的异质性髓系细胞,是树突状细胞、巨噬细胞、粒细胞的前体。这些前体细胞在病理条件下可被募集到如淋巴结、脾脏、外周血及肿瘤微环境中,并进一步诱导活化。活化后的MDSC可以通过各种机制抑制T细胞免疫反应,广泛存在于寄生虫感染的各阶段。本文就MDSC在寄生虫感染领域免疫抑制功能的研究进展作一综述。

Myeloid-derived suppressor cells(MDSCs)are a group of immature heterogeneous myeloid cells,which are the precursors of dendritic cells,macrophages,and granulocytes.These precursor cells can be recruited to microenvironments,such as lymph nodes,spleen,peripheral blood and tumor,under pathological conditions,where they are further activated.After activation,MDSCs can suppress T cell immune response through various mechanisms,which are widely involved in different stages of parasitic infection.This review summarizes the research progress on the immunosuppressive function of MDSCs in the field of parasitic infection.