Wnt信号通路在毛囊乳头细胞诱导毛囊形成及生长过程中作用的研究新进展

Recent Advances in the Role of Wnt Signaling Pathway in Hair Follicle Formation and Growth Induced by Dermal Papilla Cells

大面积脱发治疗是目前面临的难题,毛囊的体外培养与移植是很有潜力的治疗方案,但临床上极少有成功的案例。毛囊形成、生长调控机制复杂,体外培养难以模拟,在当前研究中毛囊乳头细胞诱导毛囊形成是体外毛囊培养的主要方法。Wnt信号通路在毛囊乳头细胞诱导毛囊形成和周期再生的调控中起核心作用。该文就Wnt信号通路在毛囊乳头细胞诱导毛囊形成和周期生长过程中作用的最新研究,以及近几年体外培养毛囊的新方法作一综述,希望联合不同培养方法和调控因素的体外培养能为临床大面积脱发治疗提供新的思路和依据。

Treatment of large area alopecia is a difficult problem at present.In vitro culture and transplantation of hair follicles is a potential treatment program,but there are few successful cases in clinical practice.The regulation mechanism of hair follicle formation and growth is very complex,and it is difficult to simulate in vitro culture.In the current research,hair follicle formation induced by hair follicle papilla cells is the main method of hair follicle culture in vitro,and Wnt signaling pathway plays a core role in the regulation of hair follicle formation and periodic regeneration induced by hair follicle papilla cells.This review summarizes the recent studies on the role of Wnt signaling pathway in follicle papilla cells induced follicle formation and growth cycle,and the new methods of hair follicle culture in vitro in recent years.It is hoped that in vitro culture combined with different culture methods and regulatory factors can provide new ideas and basis for clinical treatment of large area alopecia.