经鼻高流量湿化氧疗对AECOPD患者的临床疗效

The Clinical Application of Nasal High-flow Humidified Oxygen Therapy in Patients With Acute Exacerbation of COPD

目的探讨经鼻高流量湿化氧疗(high-flow nasal cannula oxygen therapy,HFNC)对慢阻肺急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床应用疗效。方法收集2018年1月—2019年12月在广东祈福医院治疗的AECOPD患者,共60例。随机分为对照组与干预组,每组各30例患者。对照组患者给予普通氧气治疗,干预组患者给予经鼻高流量湿化氧疗,比较两组患者治疗前后的血气指标(PaO2、PaCO2和pH)、慢性阻塞性肺疾病评估测试(COPD assessment test,CAT)评分和住院时间,探讨经鼻高流量湿化氧疗对慢阻肺急性加重期患者的临床疗效。结果对照组和干预组患者经过治疗后可以改善血气指标PaO2、PaCO2和pH,但干预组患者的改善效果优于对照组,差异均具有统计学意义(P<0.05);两种治疗方式均可改善患者的CAT评分,但干预组患者的改善效果优于对照组,差异均具有统计学意义(P<0.05);干预组住院时间少于观察组,差异具有统计学意义(P<0.05)。结论经鼻高流量湿化氧疗方式可以显著改善AECOPD患者的氧合状况和慢阻肺状况。

Objective To explore the clinical application of nasal high-flow humidified oxygen therapy(HFNC)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 60 patients with acute exacerbation of chronic obstructive pulmonary disease treated in Guangdong Clifford Hospital from January 2018 to December 2019 were collected.Randomly divided into a control group and an intervention group,30 patients in each group.Patients in the control group were given ordinary oxygen therapy,and patients in the intervention group were given nasal high-flow humidified oxygen therapy to compare the blood gas indexes(PaO2,PaCO2 and pH),CAT score and hospitalization time of the two groups of patients before and after treatment.To explore the clinical effect of nasal high-flow humidified oxygen therapy on patients with acute exacerbation of COPD.Results The patients in the control group and the intervention group could significantly improve the blood gas indexes PaO2,PaCO2 and pH after treatment,but the improvement effect in the intervention group was significantly better than the control group,the difference was statistically significant(P<0.05);the two treatments methods can improve the CAT score of the patients,but the improvement effect of the intervention group was better than the control group,and the differences were statistically significant(P<0.05);the hospitalization time of the intervention group was less than that of the control group,the difference was statistically significant(P<0.05).Conclusion The nasal high-flow humidified oxygen therapy can significantly improve the oxygen status and COPD status of patients with acute exacerbation of chronic obstructive pulmonary disease.