摘要
成纤维细胞激活蛋白(FAP)作为肿瘤相关成纤维细胞(CAFs)的分子标志物之一,在激活的CAFs中高度特异性表达。FAP具有促进肿瘤侵袭、转移和免疫逃逸的作用,可作为恶性肿瘤诊疗的重要靶点。镓-68标记的FAP抑制剂(^(68)Ga-FAPI)是基于FAP合成的小分子探针,经PET/CT显像可实现FAP在体内的可视化。目前,^(68)Ga-FAPI PET/CT已成功应用于神经胶质瘤、食管癌、肝细胞癌和胰腺导管腺癌等恶性肿瘤的诊断和分期。笔者综述了^(68)Ga-FAPI PET/CT在恶性肿瘤中的临床应用情况。
Fibroblast activation protein(FAP),as one of the molecular markers of cancer-associated fibroblasts(CAFs),is highly specifically expressed in activated CAFs.FAP can be used as a theranostic target for malignant tumors since it can promote tumor invasion,metastasis and immune escape.Gallium-68-labeled FAP inhibitor(^(68)Ga-FAPI)is a small molecular probe synthesized based on FAP,which can be visualized in vivo by PET/CT imaging.At present,^(68)Ga-FAPI PET/CT has been successfully used in the diagnosis and staging of glioma,esophageal cancer,hepatocellular carcinoma,pancreatic ductal adenocarcinoma and other malignant tumors.This paper reviews the clinical application of ^(68)Ga-FAPI PET/CT in malignant tumors.
作者
倪妙琪
吴爽
金晨涛
田梅
Ni Miaoqi;Wu Shuang;Jin Chentao;Tian Mei(Department of Nuclear Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China)
出处
《国际放射医学核医学杂志》
2021年第5期307-312,共6页
International Journal of Radiation Medicine and Nuclear Medicine
