HPV、TCT联合阴道镜检查对子宫颈癌筛查的临床意义

Clinical Significance of HPV and TCT Combined With Colposcopy for Cervical Cancer Screening

目的探讨人乳头瘤病毒(human papilloma virus,HPV)、液基薄层细胞检测(thinprep cytologic test,TCT)联合阴道镜检查对子宫颈癌筛查的临床意义。方法选取2018年1月—2020年1月本院收治的疑似子宫颈癌患者100例,分别为其开展HPV、TCT与阴道镜检查,分析不同检查方式与联合检查的准确率。结果本组患者病理学检查显示36例为子宫颈癌,64例为宫颈良性病变。HPV检查的准确率为54.00%,灵敏度为55.56%,特异度为53.13%;TCT检查的准确率为66.00%,灵敏度为61.11%,特异度为68.75%;联合检查的准确率为94.00%,灵敏度为94.44%,特异度为93.75%;联合检查的准确率、灵敏度与特异度均高于HPV检查与TCT检查,比较差异均有统计学意义(P<0.05)。结论HPV、TCT联合阴道镜可有效提升子宫颈癌筛查准确率,尽可能避免疾病漏诊与误诊发生。

Objective To investigate the clinical significance of human papilloma virus(HPV),thinprep cytologic test(TCT)combined with colposcopy in cervical cancer screening.Methods A total of 100 cases of suspected cervical cancer patients in our hospital from January 2018 to January 2020 were selected to carry out HPV,TCT and colposcopy respectively,and the accuracy of different examination methods and combined examination was analyzed.Results Pathological examination of this group of patients showed that 36 cases were cervical cancer and 64 cases were benign cervical lesions.The accuracy of HPV examination was 54.00%,the sensitivity was 55.56%,and the specificity was 53.13%;the accuracy of TCT examination was 66.00%,the sensitivity was 61.11%,and the specificity was 68.75%;the accuracy of the combined examination was 94.00%The sensitivity was 94.44%,and the specificity was 93.75%;the accuracy,sensitivity and specificity of the combined examination were higher than those of HPV examination and TCT examination,and the differences were statistically significant(P<0.05).Conclusion HPV,TCT combined with colposcopy can effectively improve the accuracy of cervical cancer screening and avoid missed diagnosis and misdiagnosis as much as possible.