阿奇霉素与特布他林序贯治疗小儿支原体肺炎的效果和对肺功能的影响

Effect of Azithromycin and Terbutaline in Sequential Treatment of Mycoplasma Pneumonia in Children and Its Influence on Pulmonary Function

目的分析并研究小儿支原体肺炎采取阿奇霉素、特布他林序贯治疗的临床效果及对肺功能的影响。方法研究区间为2018年1月—2019年12月,探究对象为此区段本科室接治的76例小儿支原体肺炎患儿,以就诊单双号进行组别的区分,分为对照组(n=38)和试验组(n=38),接受单一用药(阿奇霉素序贯疗法)诊疗者纳入对照组,采取双向用药者(阿奇霉素+特布他林序贯疗法)纳入试验组,对比两组效果,如总有效率、肺功能、症状缓解时间及不良反应等。结果试验组总有效率97.37%(37/38)相比于对照组的78.95%(30/38)更高(P<0.05);相比于对照组,试验组第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、呼气流量峰值(peak expiratory flow,PEF)及第1秒用力呼气容积占用力肺活量比例(the ratio of forced expiratory volume in one second to forced vital capacity,FEV1/FVC)更高(P<0.05);试验组咳嗽、湿啰音消失时间及体温恢复时间相对于对照组更早(P<0.01);两组呕吐、腹痛腹泻等不良反应比较差异无统计学无意义(P>0.05)。结论:小儿支原体肺炎采取阿奇霉素协同特布他林序贯治疗效果令人满意,可进行咳嗽、发热等症状的大幅度改善,加强肺功能,协同用药亦无明显不良反应,使用安全性较高,值得推广。

Objective To analyze and study the clinical effect of azithromycin and terbutaline sequential treatment in children with mycoplasma pneumonia and the correlation effect on lung function.Methods The study period was from January 2018 to December 2019.The subjects of investigation were 76 children with mycoplasma pneumonia treated in the undergraduate room of this section.They were divided into groups based on the single and even number of the doctor,and they could be divided into the control group.(n=38)and the experimental group(n=38),patients who received single medication(sequential azithromycin therapy)were included in the control group,and those who took two-way medication(azithromycin+terbutaline sequential therapy)were included in the experimental group.The effects of the two groups such as total effective rate,lung function,symptom relief time and adverse reactions were compared.Results The total effective rate of the experimental group was 97.37%(37/38),which was significantly higher than 78.95%(30/38)of the control group,(P<0.05);compared with the control group,the forced expiratory volume in one second(FEV1),peak expiratory flow(PEF)and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)in the experimental group were significant higher(P<0.05);the disappearance time of cough and moist rales and the recovery time of body temperature in the experimental group were significantly earlier than those in the control group(P<0.01).There was no significant difference in adverse reactions such as vomiting,abdominal pain and diarrhea between the two groups(P>0.05).Conclusion The effect of azithromycin combined with terbutaline in sequential treatment of mycoplasma pneumonia in children is satisfactory.It can significantly improve the symptoms of cough and fever,strengthen the lung function,and have no obvious adverse reactions.the use of azithromycin combined with terbutaline is safe and worthy of promotion.