针灸治疗痰湿质体质颈动脉粥样硬化的效果分析

Effect of Acupuncture and Moxibustion on Carotid Atherosclerosis With Phlegm Dampness Constitution

目的分析针灸治疗痰湿质体质颈动脉粥样硬化(atherosclerosis,AS)的临床疗效。方法选定本院2018年6月-2020年6月收治的96例痰湿质体质AS患者,以双盲随机抽样法分组,每组样本容量总计48例,对照组采纳常规西医治疗,观察组在对照组基础上采纳针灸治疗,对比两组临床疗效、斑块面积、颈动脉内-中膜厚度(intima-media thickness,IMT)、血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(high sensitive C-reactive protein,hsCRP)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平及不良反应发生率。结果治疗前,观察组患者的斑块面积、IMT、血清TNF-α、hs-CRP、MMP-9水平较对照组相比差异无统计学意义(P> 0.05);治疗后,观察组与对照组相比斑块面积、IMT、血清TNF-α、hs-CRP、MMP-9水平较低(P <0.05);观察组(95.83%)与对照组(70.83%)相比总有效率较高(P <0.05);观察组(4.17%)与对照组(18.75%)相比不良反应发生率较低(P <0.05)。结论针灸可有效降低痰湿质体质AS患者IMT,缩小斑块面积,减轻炎症反应,且不良反应较少,治疗效果好。

Objective To analyze the clinical efficacy of acupuncture and moxibustion in the treatment of phlegm dampness constitution atherosclerosis(AS).Methods A total of 96 patients with phlegm-dampness constitutional AS who were admitted to this hospital from June 2018 to June 2020 were selected and grouped by double-blind random sampling.Each group had a total sample size of 48 cases.The control group received conventional Western medical treatment,and the observation group adopted acupuncture and moxibustion on the basis of the control group,and compared the clinical efficacy,plaque area,carotid artery intima-media thickness(IMT),serum tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),matrix metalloproteinase-9(MMP-9)levels,and the incidence of adverse reactions between the two groups.Results Before treatment,the observation group had no significant difference in plaque area,IMT,serum TNF-α,hs-CRP,and MMP-9 levels compared with the control group(P>0.05);after treatment,the observation group was similar to the control group The specific plaque area,IMT,serum TNF-α,hs-CRP,MMP-9 levels were lower(P<0.05);the observation group(95.83%)had a higher total effective rate than the control group(70.83%),P<0.05;the observation group(4.17%)has a lower incidence of adverse reactions than the control group(18.75%),P<0.05.Conclusion Acupuncture and moxibustion can effectively reduce IMT,plaque area and inflammatory reaction in AS patients with phlegm dampness constitution,with less adverse reactions and good therapeutic effect.