食管癌患者放疗前NLR、hMOF蛋白及CD4^(+)/CD8^(+)水平与预后相关性研究

Study on the correlation between NLR,hMOF protein and CD4^(+)/CD8^(+) levels and prognosis of patients with esophageal cancer before radiother­apy

目的分析食管癌患者放疗前NLR、hMOF蛋白及CD4^(+)/CD8^(+)水平与预后关系。方法选取2016年1月~2020年1月入院治疗的78例食管癌患者资料进行回顾性分析,分析NLR、hMOF蛋白及CD4^(+)/CD8^(+)水平与预后相关性。结果两组在分化程度、淋巴结转移、hMOF蛋白、NLR、病变直径、CD4^(+)/CD8^(+)比较中存在显著差异(P<0.05)。低分化、有淋巴结转移、hMOF蛋白高表达、NLR高表达、病变直径≥5 cm、CD4^(+)/CD8^(+)均是影响预后不良的独立危险因素(P<0.05)。hMOF蛋白与分化程度呈正相关;NLR、CD4^(+)/CD8^(+)与分化程度、淋巴结转移呈正相关。hMOF蛋白、NLR、CD4^(+)/CD8^(+)的AUC值为0.788,0.762,0.888。结论NLR、hMOF蛋白及CD4^(+)/CD8^(+)可作为诊断食管癌及评估预后的重要指标。

Objective To analyze the relationship between NLR,hMOF protein and CD4^(+)/CD8^(+)levels and prognosis of patients with esophageal cancer before radiotherapy.Methods The data of 78 esophageal cancer patients admitted to the hospital from January 2016 to January 2020 were selected for retrospective analysis,and the correlation between NLR,hMOF protein and CD4^(+)/CD8^(+)levels and prognosis was analyzed.Results There were significant differences in the differentiation degree,lymph node metastasis,hMOF protein,NLR,lesion diameter,and CD4^(+)/CD8^(+)comparison between the two groups(P<0.05).Poor differentiation,lymph node metastasis,high expression of hMOF protein,high expression of NLR,lesion diameter≥5 cm,and CD4^(+)/CD8^(+)are independent risk factors affecting poor prognosis(P<0.05).hMOF protein is positively correlated with the degree of differentiation;NLR,CD4^(+)/CD8^(+)are positively correlated with the degree of differentiation and lymph node metastasis.The AUC values of hMOF protein,NLR,CD4^(+)/CD8^(+)were 0.788,0.762,0.888.Conclusion NLR,hMOF protein and CD4^(+)/CD8^(+)can be used as important indicators for diagnosing esophageal cancer and evaluating prognosis.