药物骨毒性临床前评价方法与其机制的研究进展

Research progress on preclinical evaluation methods and mechanisms of drug osteotoxicity

骨骼是人体重要的系统,具有支持、保护、造血、维持矿物质平衡等功能,目前药物骨毒性问题已引起全球关注,其临床前评价非常重要。药物骨毒性临床前的评价方法主要包括检测骨密度、骨组织形态学、骨强度和骨代谢指标等。Wnt/β-catenin、RANKL/RANK/OPG和BMP-2/Smads等信号通路参与调控骨代谢过程,因此深入了解这些信号通路可为药物骨毒性临床前评价提供新的思路。

Skeleton is an important system of the human body, with functions such as support, protection, hematopoiesis, and maintenance of mineral balance. At present, the problem of drug bone toxicity has attracted global attention, and the preclinical evaluation of drug bone toxicity is important. The preclinical evaluation methods of drug bone toxicity mainly include the test of bone mineral density, bone tissue morphology, bone strength and bone metabolism indicators, etc. Signal pathways such as Wnt/β-catenin, RANKL/RANK/OPG and BMP-2/Smads are involved in the regulation of bone metabolism. Therefore, in-depth understanding of these signal pathways can provide new ideas for the preclinical evaluation of drug osteotoxicity.