基于DNA模板的核酸适体-金属纳米簇在环境检测中的研究进展

Research progress of DNA-templated aptamer metal nanoclusters in environmental detection

由于优异的光学性能、良好的生物相容性、低毒性和精确可控性等优势,基于DNA模板的金属纳米簇在生物传感、生物成像和疾病治疗等领域获得了广泛的研究与应用.核酸适体作为特异性识别探针,将其与DNA模板的金属纳米簇相结合,可获得生化传感平台的新型荧光探针.本文介绍DNA模板金属纳米簇,简要概述了核酸适体-金属纳米簇的设计与合成,最后重点介绍其在环境检测方面的应用及发展前景.

DNA-templated metal nanoclusters have been widely studied and applied in the fields of biosensor,biological imaging and disease treatment because of their excellent optical properties,good biocompatibility,low toxicity and precise controllability.Novel fluorescent probes can be obtained through combining aptamers,specific recognition probes,with DNA-templated metal nanoclusters,which can be used in biochemical sensing platform.This review firstly introduced the DNA-templated metal nanoclusters,briefly outlined the design and synthesis of aptamer-metal nanoclusters,and finally focused on the application of aptamer-metal nanoclusters in environmental detection and their future perspectives.