线粒体功能障碍在胰腺疾病中的研究进展

Research progress of mitochondrial dysfunction in pancreatic diseases

线粒体功能障碍与胰腺疾病的发生发展关系密切。线粒体内膜呼吸链的电子传递和能量传递在维持细胞正常功能中发挥着重要作用,呼吸链功能失调,细胞内极易进入氧化应激状态,随即产生大量氧化中间产物攻击线粒体蛋白、DNA等,导致线粒体功能障碍,诱发胰腺炎、胰腺癌等疾病。此外,线粒体稳态在维持胰岛β细胞正常功能中起着不可或缺的作用。本文就线粒体功能障碍在胰腺疾病中的研究情况作一综述。

Mitochondrial dysfunction is closely related to the occurrence and development of benign and malignant diseases of the pancreas.Mitochondrial membrane of the respiratory chain electron transfer and energy transfer plays an important role in maintaining normal cellular function.When the respiratory chain was disrupted,the oxidative stress was increased in the cell,and produced a large number of oxide intermediate products which target mitochondrial protein,DNA,etc,lead to mitochondrial dysfunction finally induced acute pancreatitis,pancreatic cancer and other diseases.In addition,mitochondrial homeostasis plays an indispensable role in maintaining the normal function of islet cells.This paper reviewed the research status of mitochondrial dysfunction in pancreatic diseases.