序贯机械通气对重症肺炎合并呼吸衰竭患者心肺功能、炎症因子水平的影响

Effects of sequential mechanical ventilation on cardiopulmonary function and inflammatory factor levels in patients with severe pneumonia complicated with respiratory failure

目的探讨序贯机械通气对重症肺炎(SP)合并呼吸衰竭患者心肺功能、炎症因子水平的影响。方法选取我院收治的130例SP合并呼吸衰竭患者作为研究对象,按治疗方式将其分为对照组(65例,传统有创机械通气)和观察组(65例,序贯机械通气)。比较两组治疗前、后的血气指标、心肺功能指标、炎症因子水平及生存质量。结果治疗后,观察组的血气指标(PaO_(2)、SaO_(2)、PaCO_(2))、心肺功能指标(NT-proBNP、Cst、WOB)、炎症因子(IL-4、TNF-α、PCT)水平及APACHEⅡ、SGRQ评分均优于对照组(P<0.05)。结论SP合并呼吸衰竭患者采用序贯机械通气可有效改善血气指标及心肺功能指标,减轻炎症反应,提高患者生存质量。

Objective To explore the effects of sequential mechanical ventilation on cardiopulmonary function and inflammatory factor levels in patients with severe pneumonia(SP)complicated with respiratory failure.Methods A total of 130 patients with SP complicated with respiratory failure admitted in our hospital were selected as the research objects,and the patients were divided into control group(65 cases,traditional invasive mechanical ventilation)and observation group(65 cases,sequential mechanical ventilation)according to the treatment method.The blood gas indexes,cardiopulmonary function indexes,inflammatory factors levels and quality of life were compared between the two groups before and after treatment.Results After treatment,blood gas indexes(PaO_(2),SaO_(2),PaCO_(2)),cardiopulmonary function indexes(NT-proBNP,Cst,WOB),inflammatory factors(IL-4,TNF-α,PCT)levels,and APACHEⅡand SGRQ scores in the observation group were better than those in the control group(P<0.05).Conclusion Sequential mechanical ventilation in patients with SP complicated with respiratory failure can effectively ameliorate blood gas indexes and cardiopulmonary function indexes,reduce inflammatory reaction and improve the quality of life of patients.