区域性持续动脉灌注新辅助化疗治疗口腔癌的疗效观察

Efficacy of neoadjuvant chemotherapy with continuous regional arterial infusion for oral cancer

目的探讨区域性持续动脉灌注新辅助化疗对口腔癌的疗效及不良反应影响。方法选取2017年1月至2020年10月间陕西省结核病防治院第一门诊部收治的70例口腔癌患者为研究对象,采用奇偶分配法按照1:1比例进行平分,对照组35例患者采用静脉新辅助化疗,观察组35例患者采用区域性持续动脉灌注新辅助化疗,比较两组患者不同周期的治疗效果和出现的不良反应。结果观察组肿瘤控制率94.3%,与对照组的74.3%比较,差异有统计学意义(P<0.05);两组治疗有效率分别为71.4%和62.9%,差异无统计学意义(P>0.05);观察组与对照组的不良反应率分别为42.9%及40.0%,差异无统计学意义(P>0.05)。结论针对口腔癌患者,区域性持续动脉灌注新辅助化疗可提高患者生存率,患者耐受性更佳。

Objective To investigate the efficacy and adverse reactions of neoadjuvant chemotherapy with continuous regional arterial infusion for oral cancer.Methods Seven patients with oral cancer admitted to from January 2017 to October 2020 were selected,and they were equally divided according to the ratio of 1:1 by odd even distribution method.Among them,35 patients in the observation group received neoadjuvant chemotherapy with continuous regional arterial infusion and 35 patients in the control group received intravenous neoadjuvant chemotherapy.The efficacy was observed in patients receiving different treatment cycles.The adverse reactions were recorded.Results Tumor control rate was 94.3%in the observation group and 74.3%in the control group(P<0.05).The efficacy rate was 71.4%and 62.9%,respectively in the two groups(P>0.05).The incidence of adverse reactions was 42.9%in the observation group and 40.0%in the control group and there was no significant difference between the two groups(P>0.05).Conclusion In patients with oral cancer,neoadjuvant chemotherapy with continuous regional arterial infusion can improve survival rate with good tolerance.