光学相干弹性成像方法及研究进展

Advances in Optical Coherence Elastography

软组织生物力学特性的临床检测对于疾病的早期诊断、进展跟踪和疗效评估具有重要意义。光学相干弹性成像(OCE)技术是基于光学相干层析成像(OCT)发展起来的可视化生物力学测量方法,通过观测软组织器官在载荷激励下的静态或动态的力学响应来量化和重构组织器官的生物力学性能,从而获得病灶部分的病理信息。OCE技术具有非侵入的三维成像方式、实时的图像处理性能和高分辨力等优势,在软组织器官(如人眼)的临床生物力学测量方面具备独特的优势和发展潜力。从OCE的静态/动态激励方法、OCT的散斑跟踪技术和相敏探测技术以及生物力学性能量化的解析和有限元分析方法等方面对OCE的理论和方法进行了介绍,对OCE的发展历程进行了回顾,对其最新的发展现状进行了详细的介绍和总结,并对发展趋势进行了讨论。

Clinical detection of soft tissue biomechanics is of great significance for the early diagnosis,progress tracking and treatment evaluation of certain diseases.Optical coherence elastography(OCE)has been developed to visualize and quantify tissue biomechanics based on optical coherence tomography(OCT),in which to observe the static or dynamic mechanical responses of soft tissue organs under load excitation to quantify and reconstruct their biomechanical properties and thus to obtain the pathological information of diseased parts.Due to its advantages of non-invasive 3D imaging mode,real-time imaging treatment performance and high resolution,the OCE technique has the unique advantage and development potential in the clinical biomechanical measurement of soft tissue organs such as eyes.From the aspects of the static/dynamic excitation methods of OCE,the speckle tracking technology and phase sensitive detection technology of OCT,and the analytical and finite element analysis methods for biomechanical property quantification,we introduce the theory and method of OCE,review the development history of OCE,introduce and summarize in detail its newest achievements,and prospect its development trend.