TRIB3在肥胖发生中作用的研究进展

Research progress on the role of TRIB3 in obesity pathogenesis

Tribbles同源蛋白3(TRIB3,TRB3)是一种蛋白激酶抑制剂,参与细胞凋亡、应激反应、转录、调控等一系列生物过程。肥胖是由生活方式、内分泌,包括药物因素在内的多种因素引起的慢性代谢性疾病。TRIB3在体内异常表达时可能参与肥胖的发生。脂肪组织和内脏脂肪的膨胀会导致代谢紊乱、器官功能障碍、男性不育、各种慢性疾病和死亡率的增加。因此,探究TRIB3在肥胖中的作用机制有利于对肥胖的诊断及治疗提供新思路。

Tribbles homolog 3(TRIB3,TRB3)is a kind of protein kinase inhibitors involved in a variety of biological processes like apoptosis,stress response,transcription and transcriptional regulation.Obesity is a chronic metabolic disease caused by many factors including lifestyle,endocrine and drug factors.Abnormal expression of TRIB3 in vivo may be involved in the development of obesity,with expansion of adipose tissue and visceral fat leading to metabolic disorders,organ dysfunction,male infertility,various chronic diseases,and increased mortality.Therefore,exploring the mechanism of TRIB3 in obesity may provide new ideas for the diagnosis and treatment of obesity.