微光纤干涉型生物传感器

Microfiber Interferometric Biosensors

光纤生物传感器利用倏逝场效应与待测物质发生相互作用,通过检测生物识别分子与目标分子特异性结合反应引起的光信号变化实现对待测物的检测。光纤传感器由于具有尺寸小巧、可柔性弯曲等优点,从而有望为现代医学提供一种在体原位检测的新手段。微光纤干涉型生物传感器以微光纤模式干涉仪作为换能器,通过光学波导增敏和界面增敏,可实现超高灵敏度生物分子检测,甚至可达到单分子检测水平。因此,介绍了微光纤模式干涉仪原理、制备技术、折射率敏感特性、生物传感器实现和界面增敏技术。

Fiber-optic biosensors have the capability of detecting chemical or biological substance relying on the interaction of the evanescent wave to the surrounding,which probe the light signal change as a result of the specific binding of the biological recognition molecule and the target molecule. With the advantages such as small size and flexibility,fiber-optic sensors are promising to serve as an advanced methodology for in-situ bio/chemical detection.In particular,the microfiber interferometric biosensor with the microfiber modal interferometer as the energy converter can achieve ultra-high sensitivity for biomolecule detection even down to the level of single-molecule,through signal amplification by optimizing the optical waveguide structure and the interface. This review introduces the microfiber modal interferometer in terms of the principle,preparation,sensitivity characteristics,biosensor implementation and interface sensitivity enhancement.