长链非编码RNA和微小RNA相互作用参与调控肝细胞癌发生和发展的研究进展

Research progress on the interaction of Long non-coding RNA and microRNA in the regula⁃tion of the development and progression of Hepatocellular Carcinoma

原发性肝癌(PLC)是最常见的恶性肿瘤之一,其恶性程度高,发病率和死亡率均位居恶性肿瘤的前列,其中75%以上为肝细胞癌(HCC)。长链非编码RNA(lncRNAs)、微小RNA(miRNAs)等非编码RNA(ncRNAs)在肝癌细胞的增殖、分化、转移等生物学过程中发挥着重要作用,它们之间如何通过相互作用参与调控HCC的发生发展已成为肝癌研究的热点之一。本文概述了相关研究进展,为今后探索HCC的发生发展机制、临床诊断和治疗提供新的思路。

Primary liver cancer(PLC)is one of the most common malignancies with a high degree of malignancy,and its morbidity and mortality are among the leading malignancies,of which more than 75%are hepatocellular carcinoma(HCC).Non-coding RNAs(ncRNAs),such as long non-coding RNAs(lncRNAs)and microRNAs(miRNAs),play an important role in the biological processes such as proliferation,differentiation and metastasis of liver cancer cells.How they interact with each other to regulate the occurrence and development of HCC has become one of the hot spots in HCC research.This article summarizes the relevant research progress,hoping to provide new ideas for the future exploration of the occurrence and development mechanism,clinical diagnosis,and treatment of HCC.