萘酞菁衍生物在光动力疗法中的研究进展

Research Progress of Naphthalocyanine Derivatives in Photodynamic Therapy

光动力治疗作为一种非侵入性治疗方式,具有微创、毒副作用小、可重复治疗等优点。光敏剂是光动力治疗的关键因素之一,萘酞菁作为第二代光敏剂,扩展的π-共轭体系使其在750~900 nm具有强吸收,该近红外光有较深的组织穿透性,且能量足够激发光敏剂,也能避免可见光区吸收带来的皮肤光毒性。但萘酞菁具有较强的聚集倾向,影响其光化学性质及光动力疗效。综述了通过合成萘酞菁衍生物和纳米载体包封来改善其光学性质或增强光动力疗效的进展。

As a non-invasive treatment,photodynamic therapy has the advantages of minimally invasive,less toxic and side effect,and repeatable treatment.Photosensitizer is one of the key factors of photodynamic therapy.Naphthalocyanine is the second generation photosensitizer,the expandedπ-conjugated system makes it have strong absorption at 750~900 nm which has deep tissue penetration,and the energy is enough to stimulate the photosensitizer,photosensitizer in near infrared region can also avoid the skin phototoxicity caused by absorbing the visible region.However,naphthalocyanine has a strong aggregation tendency,which affects its photochemical properties and photodynamic efficacy.This paper reviews the progress in the synthesis of naphthalocyanine derivatives and nano-carrier encapsulation to improve their optical properties or enhance photodynamic efficacy.