多金属氧酸盐抗RNA病毒的研究进展

Research Progress of Polyoxometalates Against RNA Viruses

RNA病毒是病毒家族的重要成员,由于其变异快、疫苗较难开发,世界各地每年都会有几种RNA病毒爆发,严重威胁人类的生命健康。多金属氧酸盐由于可以在分子水平上设计空间结构,且对正常细胞无毒,所以在医学上具有很好的应用前景。综述了近20年多金属氧酸盐对粘病毒(流感病毒、呼吸道合胞病毒)、黄病毒(丙型肝炎病毒、寨卡病毒)和慢病毒(人类免疫缺陷病毒1型)等RNA病毒作用的研究进展,发现多金属氧酸盐具有广谱抗病毒活性,为开发高效的抗病毒新药提供参考。

RNA viruses are important members of the virus family.Several RNA viruses break out all over the world every year and the rapid mutations make the development of vaccines to be difficult,so they threaten human life and health seriously.Since polyoxometalates′spatial structures can be designed at the molecular level and are non-toxic to normal cells,they have very promising potential in medicine field.This article reviews the effects of polyoxometalates on RNA viruses such as myxoviruses(influenza virus,respiratory syncytial virus),flavivirus(hepatitis C virus,Zika virus)and lentivirus(human immunodeficiency virus type 1)in the past 20 years.The research progress indicated that polyoxometalates had broad-spectrum antiviral activity,and would provide a reference for the development of highly effective new antiviral drugs.