以甲酸及其铵盐为原料的N-甲酰化反应新进展

Recent Progress in the N-Formylation Reactions Using Formic Acid and Its Ammonium Salt as Substrates

甲酰胺是合成药物、染料和香料的有机中间体和重要的工业合成原料,同时在作为工业溶剂和路易斯碱催化剂方面也发挥着重要作用,发展简单、绿色和经济的甲酰胺合成方法引起合成化学和工业领域的广泛关注。近年来,以生物质来源的甲酸及甲酸铵为原料的N-甲酰化反应研究得到了快速发展,许多新颖的合成方法和具有工业应用价值的研究成果不断涌现。从胺的直接甲酰化及硝基或含氮杂环化合物的还原甲酰化方面着手,综述了N-甲酰化反应研究的新进展。

Formamides as organic intermediates in the synthesis of pharmaceuticals,dye and flavor are one of valuable substrates in industrial synthesis.Formamides have also played significant roles as industrial solvents and Lewis base catalysts,and the development of simple,green and economic strategy to synthesize formamides has always attracted extensive attention in synthetic chemistry and industry.The rapid developments in the N-formylations have been obtained and many novel methods and attractive achievements using formic acid and formamide as substrates from biomass have been made in recent years.This paper reviews recent advances on the direct N-formylations of amines and reduction and N-formylations of nitro-compounds or heterocycles including nitrogen atom.