前列地尔联合泮托拉唑钠治疗在急性胰腺炎患者中的应用

Application of Alprostadil combined with Pantoprazole Sodium in the treatment of patients with acute pancreatitis

目的探讨前列地尔联合泮托拉唑钠治疗在急性胰腺炎患者中的应用。方法选取2018年2月—2020年2月常熟市第一人民医院消化内科收治的58例急性胰腺炎患者作为研究对象,采用随机数字表法将其分为对照组与研究组,每组各29例。对照组患者采用泮托拉唑钠治疗,研究组患者采用前列地尔联合泮托拉唑钠治疗。比较两组患者治疗5、10 d时的血淀粉酶阴转率、体征缓解或消失率、症状缓解或消失率、临床效果及血流动力学指标。结果研究组患者治疗5、10 d时的血淀粉酶阴转率、体征缓解或消失率、症状缓解或消失率均高于对照组,差异有统计学意义(P<0.05)。研究组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。研究组患者治疗后的脑血管阻力(CVR)、平均动脉压(MAP)高于对照组,心率(HR)低于对照组,差异有统计学意义(P<0.05)。结论急性胰腺炎患者治疗中使用前列地尔联合泮托拉唑钠较单用泮托拉唑钠能更好地改善患者的体征、症状及血流动力学指标,具有更显著的治疗效果,应用价值更高,值得临床推广。

Objective To explore the application of Alprostadil combined with Pantoprazole Sodium in the treatment of patients with acute pancreatitis.Methods A total of 58 patients with acute pancreatitis in the Department of Gastroenterology of the First the People′s Hospital of Changshu City from February 2018 to February 2020 were selected as the research objects and divided into the control group and the study group according to random number table method,with 29 cases in each group.The control group was treated with Pantoprazole Sodium,and the study group was treated with Alprostadil combined with Pantoprazole Sodium.The negative conversion rate of blood amylase,the rate of relief or disappearance of signs,the rate of relief or disappearance of symptoms,the clinical effect and the hemodynamic indexes were compared between the two groups after 5 and 10 days of treatment.Results The blood amylase negative conversion rate,sign remission or disappearance rate,symptom remission or disappearance rate of the study group were higher than those of the control group at 5 and 10 days after treatment,and the differences were statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The cerebrovascular resistance(CVR),mean arterial pressure(MAP)of the study group after treatment were higher than those of the control group,and the heart rate(HR)was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion Compared with Pantoprazole Sodium alone,Proprostadil combined with Pantoprazole Sodium in the treatment of acute pancreatitis can better relieve the signs and symptoms of patients,improve the hemodynamics,have more significant therapeutic effect,have higher application value,and are worthy of clinical promotion.