NF-κB p65蛋白在皮肤鳞状细胞癌中的表达分析

Expression analysis of NF-κB p65 protein in skin squamous cell carcinoma

目的探讨NF-κB p65蛋白在皮肤鳞状细胞癌中的表达。方法选择贵州医科大学附属医院和赣南医学院第一附属医院2018年1月—2019年12月收治的50例皮肤鳞状细胞癌患者病理组织切片作为癌组织组,相对应癌旁组织50例进行对照。比较两组NF-κB p65蛋白的表达差异,并对NF-κB p65蛋白在皮肤鳞状细胞癌表达情况与患者性别、年龄、疾病临床分期和分化程度的关系进行分析。结果癌组织组的NF-κB p65蛋白表达阳性率高于癌旁组织组,差异有统计学意义(P<0.05)。患者不同性别、年龄情况下的NF-κB p65蛋白在皮肤鳞状细胞癌中的表达情况比较,差异无统计学意义(P>0.05)。Ⅲ~Ⅳ期患者的NF-κB p65蛋白表达阳性率高于Ⅰ~Ⅱ期患者,差异有统计学意义(P<0.05)。低分化患者的NF-κB p65蛋白表达阳性率高于高中分化患者,差异有统计学意义(P<0.05)。结论NF-κB p65蛋白在皮肤鳞状细胞癌中的表达高于癌旁组织,且皮肤鳞状细胞癌的分期越高,则NF-κB p65蛋白表达越高;皮肤鳞状细胞癌的分化程度越低,则NF-κB p65蛋白表达越高。而NF-κB p65蛋白表达和患者的年龄、性别之间没有明显的关系。

Objective To investigate the expression of NF-κB p65 protein in skin squamous cell carcinoma.Methods The pathological sections of 50 patients with skin squamous cell carcinoma treated in the Affiliated Hospital of Guizhou Medical University and the First Affiliated Hospital of Gannan Medical University from January 2018 to December 2019 were selected as cancer tissue group,and 50 cases of paracancerous tissue was selected as control group.The expression of NF-κB p65 protein was compared between the two groups.The relationship between the expression of NF-κB p65 protein in skin squamous cell carcinoma and the patient′s gender,age,clinical stage and degree of differentiation was analyzed.Results The positive rate of NF-κB p65 protein expression in the cancer tissue group was higher than that in the paracancerous tissue group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the expression of NF-κB p65 protein in skin squamous cell carcinoma under different genders and ages(P>0.05).The positive rate of NF-κB p65 protein expression in patients with stageⅢ-Ⅳwas higher than that of patients with stageⅠ-Ⅱ,and the difference was statistically significant(P<0.05).The positive rate of NF-κB p65 protein expression in poorly differentiated patients was higher than that in highly differentiated patients,and the difference was statistically significant(P<0.05).Conclusion The expression of NF-κB p65 protein in skin squamous cell carcinoma is higher than that in paracancerous tissue,and the higher the stage of skin squamous cell carcinoma is,the higher the expression of NF-κB p65 protein is,and the lower the degree of differentiation of skin squamous cell carcinoma is,the higher the expression of NF-κB p65 protein is.However,there is no significant relationship between the expression of NF-κB p65 protein and the age and gender of the patients.