非小细胞肺癌中表皮生长因子受体罕见突变的研究进展

Progress of rare epidermal growth factor receptor mutations in non-small cell lung cancer

随着生物分子诊断技术和基因分析的发展,逐步发现某些基因的异常可驱动肺癌的发生、发展,其中表皮生长因子受体(EGFR)是非小细胞肺癌(NSCLC)最常见的突变基因类型。然而目前研究大多针对EGFR的常见突变,即第19号外显子缺失(19del)及第21号外显子点突变(L858R),对EGFR罕见突变的研究较少,文章对现阶段NSCLC中EGFR罕见突变的研究进展进行综述。

With the development of biomolecular diagnostic technology and genetic analysis,it has been gradually discovered that some gene abnormalities can drive the occurrence and development of lung cancer.Among them,epidermal growth factor receptor(EGFR)is the most common mutant gene in non-small cell lung cancer(NSCLC).However,most of the current researches focus on the common mutations of EGFR,such as exon 19 deletion(19del)and exon 21 point mutation(L858R).There are few studies on rare EGFR mutations.This article reviews the progress of rare EGFR mutations in NSCLC.