基于数据挖掘的慢性盆腔炎口服用药规律分析

Rule of Oral Administration in the Treatment of Chronic Pelvic Inflammatory Disease Based on Data Mining

目的:运用数据挖掘技术探讨中药治疗慢性盆腔炎的口服用药规律,为中医临床治疗慢性盆腔炎及相关中成药的研发提供参考。方法:检索中国知网(CNKI)、万方数据库、维普期刊资源数据库中2003年1月至2020年1月发表的口服中药汤剂治疗慢性盆腔炎的相关文献,筛选出符合纳排标准的中药处方信息输入Excel表,建立数据库。借助SPSS Statistic 25.0和SPSS Modeler 18.0软件对数据进行描述性分析、系统聚类分析、因子分析和关联规则分析。结果:本研究共纳入104个处方、174味中药。将使用频次>18的中药视为高频药,共有20味,排在前5位的分别是赤芍、当归、败酱草、延胡索、甘草。高频药属类以清热药、活血化瘀药、补虚药为主;归经以肝、脾、心为主,四气以寒、温、平为主,五味以苦、甘、辛为主,共得到5个聚类组合、8个因子组合和23条关联规则,综合挖掘出3组核心药物组合。结论:慢性盆腔炎的治则以清热解毒利湿、补气化瘀消癥为主,疏肝理气、缓急止痛为辅。

Objective:Data mining technology was used to explore the rule of oral administration of traditional Chinese medicine(TCM)in the treatment of chronic pelvic inflammatory disease,with a prospect of providing reference for the clinical treatment of chronic pelvic inflammatory disease and related Chinese patent medicine research and development.Methods:Literature on the treatment of chronic pelvic inflammatory disease with oral TCM decoction was retrieved from CNKI,Wanfang and VIP databases from January 2003 to January 2020,and the TCM prescription information meeting the inclusion and exclusion criteria was selected and input into Excel to establish the database.Descriptive analysis,system clustering analysis,factor analysis and association rule analysis were performed on the data by SPSS Statistic 25.0 and SPSS Modeler 18.0 software.Results:A total of 104 prescriptions and 174 herbs were included in this study.The traditional Chinese medicines with more than 18 times of use were regarded as high frequency medicine,and there were a total of 20 kinds.The top 5 were Chishao(Paeoniae Radix Rubra),Danggui(Angelicae Sinensis Radix),Baijiangcao(Herba Patriniae),Yanhusuo(Corydalis Rhizoma),Gancao(Glycyrrhizae Radix Et Rhizoma).High-frequency drugs were mainly heat clearing drugs,blood activating and blood stasis removing drugs,deficiency tonifying drugs.The meridian tropism was mainly liver,spleen and heart.The four properties mainly included the cold,warm and smooth,and the five tastes mainly included bitter,sweet and hot.A total of 5 cluster combinations,8 factor combinations and 23 association rules were obtained,and 3 groups of core drug combinations were excavated comprehensively.Conclusions:The treatment of chronic pelvic inflammatory disease is mainly to clear away heat,detoxify dampness,replenish qi,remove blood stasis and eliminate swelling,which is supplemented by regulating liver and qi and relieving pain.