摘要
目的:比较无创高频振荡通气(non-invasive high frequency oscillation ventilation,NHFOV)和经鼻持续气道正压通气(nasal continuous positive airway pressure,NCPAP)在早产儿拔管后呼吸支持治疗的安全性及有效性。方法:收集2018年9月-2021年3月重庆市江津区中心医院新生儿科NICU收治的胎龄≥32周早产儿70例,通过查阅随机数字表随机分成两组:治疗组接受NHFOV治疗(n=35);对照组接受NCPAP治疗(n=35)。主要评价指标:72 h内撤机成功率及无创呼吸支持时间;次要评价指标:气胸、支气管肺发育不良(bronchopulmonary dysplasia,BPD)及脑室内出血(intraventricular hemorrhage,IVH)发生率。结果:NHFOV组在撤离有创机械通气后72 h内撤机成功率明显高于NCPAP组,差异有统计学意义(χ^(2)=5.714,P=0.034);两组次要评价指标比较差异均无统计学意义。结论:与NCPAP比较,NHFOV作为早产儿撤机后无创呼吸支持可以提高撤机成功率,是一种有效的无创辅助通气治疗方式,但广泛应用于临床尚需进一步研究。
Objective To compare the efficacy and safety of non-invasive high-frequency oscillatory ventilation(NHFOV)with nasal continuous positive airway pressure(NCPAP)in preterm infants as post-extubation respiratory support.Methods A total of 70 neonates admitted to department of neonatology of Jiangjin District Central Hospital during September 2019 to March 2021 were recruited,and randomized to NHFOV group(n=35)and NCPAP group(n=35)by randomized digital table.The primary outcomes were the rate of successful extubation within 72 h and non-invasive respiratory ventilation support time.Secondary outcomes included incidences of pneumothorax,bronchopulmonary dysplasia(BPD),and intracranial hemorrhage(IVH).Results Compared with NCPAP group,NHFOV group had significantly higher rate of successful extubation within 72 h(χ^(2)=5.714,P=0.034).There were no statistically differences in all other secondary outcomes between the 2 groups(P>0.05).Conclusion NHFOV can improve the success rate of weaning as compared with NCPAP in preterm infants after extubation.NHFOV is effective as ventilation support in preterm infants after extubation.Larger multicentre studies are required for exploring benefits of nHFOV.
作者
张慧
付宏
ZHANG Hui;FU Hong(Department of Neonatology,Chongqing jiangjin district Central Hospital,Chongqing 402260,China)
出处
《湖北医药学院学报》
CAS
2021年第4期391-395,共5页
Journal of Hubei University of Medicine
基金
重庆市江津区科技计划项目(Y2018042)。
关键词
早产儿
无创高频振荡通气
经鼻持续气道正压通气
Preterm infants
Non-invasive high-frequency oscillatory ventilation
Nasal continuous positive airway pressure