重度子痫前期孕妇应用硝苯地平联合硫酸镁治疗效果及对孕妇妊娠结局的影响

Effect of Nifedipine Combined with Magnesium Sulfate on Pregnancy Outcome of Pregnant Women with Severe Preeclampsia

目的:探讨重度子痫前期孕妇应用硝苯地平联合硫酸镁治疗效果及对孕妇妊娠结局的影响。方法:回顾性分析2016年1月-2021年1月我院收治的317例重度子痫前期孕妇作为研究对象,按照治疗方法不同分为两组,对照组117例予以硫酸镁治疗,研究组200例予以硝苯地平联合硫酸镁治疗,比较两组治疗效果、血压、心率、24 h尿蛋白妊娠结局及并发症发生情况。结果:研究组总有效率高于对照组(95.00%vs 68.38%),差异有统计学意义(P <0.05);治疗后,研究组血压、心率、24 h尿蛋白低于对照组,差异有统计学意义(P<0.05);研究组妊娠结局优于对照组,并发症总发生率均低于对照组,差异有统计学意义(P<0.05)。结论:硝苯地平联合硫酸镁治疗重度子痫前期孕妇效果满意,可有效控制血压水平,降低新生儿窒息或窘迫等不良妊娠结局发生概率,提升产妇生产安全性。

Objective: To investigate the effect of nifedipine combined with magnesium sulfate in the treatment of pregnant women with severe preeclampsia and its effect on pregnancy outcome. Methods: Totally 317 cases of pregnant women with severe preeclampsia admitted to our hospital from January 2016 to January 2021 were retrospectively analyzed. According to different treatment methods, they were divided into two groups, control group with 117 cases were treated with magnesium sulfate, and study group with 200 cases were treated with nifedipine combined with magnesium sulfate. The treatment effect, blood pressure, heart rate, 24 h urinary protein, pregnancy outcome and complications were compared between the two groups. Results: The effective rate of the study group was higher than that of the control group(95.00% VS 68.38%), the difference was statistically significant(P<0.05);after treatment, the level of blood pressure, heart rate and 24 h urinary protein in the study group were lower than those in the control group, the difference was statistically significant(P<0.05);the pregnancy outcome of the study group was better than that of the control group, the total incidence of complications was lower than that of the control group, the difference was statistically significant(P<0.05). Conclusion: The effect of nifedipine combined with magnesium sulfate in the treatment of severe preeclampsia is satisfactory, which can effectively control blood pressure, reduce the incidence of adverse pregnancy outcomes such as neonatal asphyxia or distress, and improve the safety of childbirth.