易坦静长期佐治儿童支气管哮喘的安全性以及药物依赖情况

The safety of Yitanjing in the Long-term Treatment of Bronchial Asthma in Children and the Status of Drug Dependence

目的:探讨易坦静长期治疗儿童支气管哮喘的安全性以及药物依赖情况。方法:回顾性分析我院2019年1月-2020年1月期间收治的87例支气管哮喘患儿。根据其治疗药物的不同分为两组。观察组(n=44)在基础治疗的基础上采用易坦静治疗,对照组(n=43)在基础治疗的基础上采用氨茶碱治疗。患儿均连续治疗3个月以上。分析两组患儿的哮喘控制情况、第一秒最大呼气量(FEV1)、用力肺活量(FVC)、第一秒用力呼气容积占用力肺活量百分比(FEV1/FVC)、最大呼气流速峰值(PEF)、不良反应发生率及药物依赖评分。结果:治疗3个月时,观察组中哮喘完全控制率高于对照组(79.54%>58.14%),差异有统计学意义(χ^(2)=4.656,P <0.05);两组患儿的肺功能指标均较治疗前显著改善,差异有统计学意义(P <0.05);观察组FEV1、FVC、FEV1/FVC、PEF水平与对照组相近,差异无统计学意义(P> 0.05);观察组患儿的心律失常(45.45%)、胃肠不适(43.18%)、血压升高(47.73%)发生率高于对照组,差异有统计学意义(χ^(2)=16.556、10.839、9.854,P <0.05);观察组的药物依赖性评分为(29.56±3.17)分,高于对照组的(18.79±3.62)分,差异有统计学意义(t=14.773,P<0.05)。结论:在支气管哮喘患儿的长期治疗中,使用易坦静可显著改善患儿的哮喘发作情况,提升患儿的肺功能,但其可导致轻度的药物依赖,且易对患儿的心肌功能造成不良影响。

Objective: To explore the safety of Yi tanjing in the long-term treatment of bronchial asthma in children and the status of drug dependence. Methods: A retrospective analysis of 87 children with bronchial asthma in our hospital from January 2019 to January 2020. They were divided into two groups according to the different drugs. Both groups of patients received basic treatment, and on this basis, the observation group(n = 44) was treated with Yitanjing, and the control group(n = 43) was treated with aminophylline. All patients were treated continuously for more than 3 months. Asthma control, FEV1, FVC, FEV1/FVC, PEF, incidence of adverse reactions and drug dependence score were analyzed. Results: after 3 months of treatment, the complete control rate of asthma in the observation group was 79.54%, which was higher than 58.14% in the control group(χ^(2)= 4. 656, P < 0.05);The lung function indexes of the two groups were significantly improved compared with those before treatment(P<0.05);The levels of FEV1, FVC, FEV1/FVC and PEF in the observation group were similar to those in the control group(P > 0.05);The incidences of arrhythmia(45.45%), gastrointestinal discomfort(43.18%) and elevated blood pressure(47.73%) in the observation group were higher than those in the control group(χ^(2)= 16.556, 10.839, 9.854, P < 0.05);The score of drug dependence in the observation group was(29.56±3.17), higher than(18.79±3. 62) The difference was statistically significant(t = 14.773, P < 0.05). Conclusion: In the long-term treatment of children with bronchial asthma, Yitanjing can significantly improve the asthma attack and lung function of children, but it can lead to mild drug dependence and adverse effects on myocardial function.