鼻咽癌的治疗进展

Progress in the treatment for nasopharyngeal carcinoma

鼻咽癌(nasopharyngeal carcinoma,NPC)与爱泼斯坦-巴尔病毒(Epstein Barr virus,EBV)密切相关,多发生在中国南部和东南亚国家。因为NPC解剖的特殊性及放疗敏感性,对早期患者行单纯放疗可取得令人满意的疗效。但大多NPC患者确诊时已属于局部晚期,对于这部分患者,以放疗为基础的综合治疗逐渐成为主要手段。如何提高患者的治疗效果及生存质量仍是NPC治疗的一大挑战。文章讨论NPC放化疗的发展和方案选择,及靶向治疗、免疫治疗及鼻内镜手术等新兴技术的发展状况,就近年来NPC的综合治疗作一论述。

Nasopharyngeal carcinoma(NPC)is closely related to Epstein-Barr virus(EBV),which mostly occurs in south China and Southeast Asian countries. Because of the anatomical limitation of NPC and its sensitivity of radiotherapy,radiotherapy can achieve satisfactory results for early patients,However,most patients with NPC are locally advanced when they are diagnosed,for these patients,comprehensive treatment based on radiotherapy has gradually become the main means of treatment. How to improve the treatment effect and life quality of patients with NPC is still a big challenge. In this paper,the development of chemoradiotherapy and the choice of chemotherapy regimens,as well as the development of new technologies such as targeted therapy,immunotherapy and surgery are discussed.